Optimizing regional infusion treatment strategies for melanoma of the extremities

Regional Perfusion for Melanoma of the Extremities

_____________ _ A common cause for treatment failure in patients with malignant melanoma is local or regional recurrence of the disease. It is presumed that the poor treatment response rate is due to occult metastases present during the initial treatment phase. In an effort to improve response rate and survival, 15 patients with malignant melanoma of an extremity underwent isolated regional lim...

Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.

Five different human melanoma xenografts were used in a xenograft model of extremity melanoma to evaluate the variability of tumor response to regionally administered melphalan or temozolomide and to determine if various components of pertinent drug resistance pathways for melphalan [glutathione S-transferase (GST)/glutathione] and temozolomide [O(6)-alkylguanine DNA alkyltranferase (AGT)/misma...

Strategies for optimizing treatment outcomes.

The relationship between increased levels of cholesterol and elevated risk for coronary heart disease (CHD) has been described in many epidemiological and well-designed prospective trials. Additionally, since first being elucidated by the Coronary Primary Prevention Trial, numerous trials have demonstrated that reducing blood cholesterol levels results in a corresponding reduction in risk for C...

New therapeutical approaches for the treatment of malignant Melanoma

formation and evolution of regional organizations: the case study of the economic cooperation organization (eco)

abstract because of the many geopolitical, geo economical and geo strategically potentials and communicational capabilities of eco region, members can expand the convergence and the integration in base of this organization that have important impact on members development and expanding peace in international and regional level. based on quality analyzing of library findings and experts interv...